Publications (Selected)




Chung C, Cho HJ, Lee CE, Koo JH (2022) Odorant receptors in cancer. BMB Reports 55(2):72-80.


Choi W, Ryu SE, Cheon Y, Park Y-J, Kim S, Kim E, Koo JH, Choi H, Moon C, Kim K (2022) A single chemosensory GPCR is required for a concentration-dependent behavioral switching in C. elegans. Current Biology 32(2):398-411.


Cho HJ and Koo JH (2021) Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas: a systematic analysis and review. BMB Reports 54(12): 601-607.


Vadevoo SMP, Gunassekaran GR, Lee CE, Lee NH, Lee J, Chae S., Park J-Y, Koo JH**, Lee B** (2021) The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages. Proc. Natl. Acad. Sci. U.S.A. 118(37):e2102434118.  


Lee N, Jae Y, Kim M, Cho TH, Lee CE, Hong YR, Hyeon DY, Ahn S, Kwon H, Kim K, Jung JH, ChaeS, Shin JO, Bok J, Byun Y, Hwang D, Koo J. (2020) A pathogen-derived metabolite induces microglial activation via odorant receptors. FEBS J. 287(17):3841-3870. 


Cho TH*, Lee CE*, Lee NH, Hong YR, Koo JH (2019) Small-chain fatty acid activates astrocytic odorant receptor Olfr920. Biochem Biophys Res Commun. 510: 383-387. 


Lee NH*, Sa M*, Hong YR, Lee CJ**, Koo JH** (2018) Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a GαsProtein-coupled Receptor. Exp Neurobiol. 27(5):365-376. 


Kang CW, Han YE, Lee MK, Cho YH, Kang NN, Koo JH, Ku CR, Lee, EJ (2018) Olfactory marker protein regulates prolactin secretion and production by modulating Ca2+ and TRH signaling in lactotrophs.  Exp Mol Med 50(4): 15. doi: 10.1038/s12276-018-0035-z. 


Kim YH*, Lee NH*, Park BB, Jae YG, Ok K, Kang NN, Hong YR, Choi S, Jeon YH, Lee EH, Byun Y**, Koo JH** (2017) Analogue of dehydroacetic acid as a selective and potent agonist of ectopic odorant receptor by a combination of hydrophilic and hydrophobic interactions. ChemMedChem 12(7):477-482. 


Kim JH and Koo JH (2017) Ectopic odorant receptor: expression and function. 2017(1) TiBMB, KSBMB Webzine. 


Kim H*, Kang NN*, An KH, Kim D, Koo JH**, Kim MS** (2016) MRPrimerV: A database of PCR primers for RNA virus detection. Nucleic Acids Res. 45(D1): D475-D481.


Kim H*, Kang NN*, An KH, Koo JH**, Kim M-S** (2016) MRPrimerW: A tool for rapid design of valid high-quality primers for multiple target qPCR experiments. Nucleic Acids Res. 44(W1):W259-66. 


Kim H*, Kang NN*, Chon KW, Kim S, Koo JH**, Kim MS** (2015) MRPrimer: A MapReduce-based design method for the through design of valid and ranked primers for PCR. Nucleic acids Res. 43(20):e130. 


Kang NN*, Bahk YY*, Lee NH, Jae YG, Cho YH, Ku CR, Byun Y, Lee EJ, Kim MS, Koo JH (2015) Olfactory receptor Olfr544 responding to azelaic acid regulates glucagon secretion in α-cells of mouse pancreatic islets. Biochem Biophys Res Commun. 460(3):616-621. 


Kim S-H, Yoon YC, Lee AS, Kang NN, Koo JH, Rhyu MR, Park J-H (2015) Expression of human olfactory receptor 10J5 in heart aorta, coronary artery, and endothelial cells and its functional role in angiogenesis. Biochem Biophys Res Commun. 460(2):404-408. 


Kang NN*, Kim H*, Jae YG*, Lee NH, Ku CR, Margolis FL, Lee EJ, Bahk YY, Kim MS**, Koo JH** (2015) Olfactory marker protein expression is an indicator of olfactory receptor-associated events in non-olfactory tissues. PLoS ONE. 10(1):e116097. 


Lee NH*, Jung YS*, Lee HY, Kang NN, Park YJ, Hwang JS, Bahk YY, Koo JH**, and Bae YS** (2014) Mouse neutrophils express functional umami taste receptor T1R1/T1R3. BMB Rep. 47(11):649-654. 


Koo JH** and Byun Y** (2013) Current Status of PET-Imaging Probes of β–Amyloid Plaques. Arch Pharm Res 36(10):1178-1184. 


Kang NN and Koo JH (2012) Olfactory receptor in non-chemosensory tissues. BMB reports 45 (11):612-622. 


Khazaei MR, Halfter H, Karimzadeh F, Koo JH, Margolis FL, Young P. (2010) Bex1 is involved in the regeneration of axons after injury. J Neurochem. 115(4):910-920.


Koo JH (2010) Bex1 participates in muscle regeneration by regulating myogenic satellite cell differentiation. Lab Anim Res. 26(2):145-151.


Kwon HJ*, Koo JH*, Zufall F, Leinders-Zufall T, Margolis FL. (2009) Ca extrusion by NCX is compromised in olfactory sensory neurons of OMP mice. PLoS ONE. 4(1):e4260.


Koo JH**, Smiley MA, Lovering RM, Margolis FL. (2007) Bex1 knockout mice show altered skeletal muscle regeneration. Biochem Biophys Res Commun. 363(2):405-410.


Pyrski MM*, Koo JH*, Polumuri SK, Ruknudin AM, Margolis JW, Schulze DH, Margolis FL. (2007) Sodium/calcium exchanger expression in the mouse and rat olfactory systems. J Comp Neurol. 501(6):944-958.


Bernstein SL, Koo JH, Slater BJ, Guo Y, Margolis FL. (2006) Analysis of optic nerve stroke by retinal Bex expression. Mol Vis. 12:147-55.


Margolis FL, Koo JH. (2006) Olfactory marker protein (OMP) from PAGE band to structure and function: An overview. Wako Jyunyaku Jiho. 74:9-12.


Koo JH, Santasas M, Margolis FL. (2005) Immunolocalization of Bex protein in the mouse brain and olfactory system. J Comp Neurol. 487(1):1-14.


Koo JH, Gill S, Pannell L, Menco Ph. M, Margolis JW, Margolis FL. (2004) The interaction of Bex and OMP reveals a dimer of OMP with a short half-life. J Neurochem. 90(1):102-116.


Baldisseri DM, Margolis JW, Weber DJ, Koo JH, Margolis FL. (2002) Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction. J Mol Biol 319(3):823-837.


*These authors contributed equally.

** indicates a corresponding author